Who is suitable for Duodopa? Who is not?

Duodopa is indicated for advanced levodopa-responsive Parkinson’s disease with severe motor fluctuations and hyperkinesia or dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory results.1

Your patient may be a suitable for Duodopa if he or she has advanced Parkinson’s disease and is:1

  • Levodopa-responsive and
  • Having severe motor fluctuations and hyperkinesia or dyskinesia despite optimised oral Parkinson's disease medications and
  • Appropriate for the PEG-J procedure; a radiological gastro jejunostomy may be considered if percutaneous endoscopic gastrostomy is not suitable

Duodopa is not suitable for patients who are not clinically eligible or have:1

  • Hypersensitivity to levodopa or carbidopa
  • Narrow-angle glaucoma
  • Severe heart failure
  • Severe cardiac arrhythmia
  • Acute stroke
  • Non-selective MAO inhibitors or selective MAO type A inhibitors. These are contraindicated for use with Duodopa and must be discontinued at least two weeks prior to initiating therapy with Duodopa. However, Duodopa may be administered concomitantly with the manufacturer's recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g. selegiline HCl)
  • Conditions in which adrenergics are contraindicated, e.g. pheochromocytoma, hyperthyroidism and Cushing's syndrome

Find a Duodopa initiation centre in your area
PD NHS Specialist Centres in England and Scotland

For a full service directory contact your AbbVie Representative or request one using the form here

Starting patients on Duodopa

  1. The clinical team at the specialist centre makes the decision to treat a patient with Duodopa
  2. Complete titration form and return to Duodopacoordinator@nhs.net
  3. Then, complete the initiation supply form and return to Duodopacoordinator@nhs.net

To obtain the relevant forms or contact the Duodopa co-ordinator click here

The Duodopa co-ordinator will liaise with the relevant Bed Manager, Gastroscopist and Duodopa Nurse Specialist to make bookings for the patient’s PEG/J procedure and Duodopa titration, and will be your main point of contact for any queries relating to management of Duodopa.